Thomas M. Wisniewski, MD

Specialties: Neurology, Neuropathology

Dr. Thomas Wisniewski is a board-certified neurologist and neuropathologist and is the Director of the NYU Pearl Barlow Center for Memory Evaluation and Treatment. Dr. Wisniewski operates an active research laboratory focusing on neurodegenerative disorders with a particular focus on the mechanisms that drive amyloid deposition in Alzheimer’s and prion diseases. This work has led to over 300 peer-reviewed publications, 25 issued patents, and continuous funding from the NIH for over 26 years.

Dr. Wisniewski’s lab has made key discoveries in gaining a greater understanding of possible therapeutic interventions, including discovering the role of apolipoprotein E (APOE) in driving amyloid deposition in late-onset Alzheimer’s disease. Dr. Wisniewski coined the term “pathological chaperone” to denote the role of APOE, even before the discovery of the link between the APOE E4 allele and late-onset Alzheimer’s disease. His lab also develops strategies for the enhanced clearance of pathological conformations of both amyloid beta and tau proteins in Alzheimer’s disease, using both active and passive immunization approaches, specifically through targeting toxic oligomeric species as well as through the stimulation of innate immunity via agonists of Toll-like receptor 9. These approaches have been highly efficacious in several rodent and non-human primate models of Alzheimer’s and prion diseases.

Dr. Wisniewski’s career has been dedicated to researching and developing treatments for numerous conditions including Alzheimer’s disease, mild cognitive impairment, Lewy body dementia, frontotemporal dementia, prion disease, Jakob-Creutzfeldt disease, multiple system atrophy and memory loss. This has led him to receive numerous awards, honors and recognitions including being elected as a Distinguished Fellow in 2014, receiving the 2009 Prion Prize, the Alzheimer’s Association Zenith Award in 2002 and being recognized every year by “Best Doctors in America” since 2008. Dr. Wisniewski has been an Associate Editor for the Journal of Alzheimer’s Disease and Chief Editor of Frontiers in Aging Neuroscience since 2018.

Dr. Wisniewski earned his MD at King’s College London GKT School of Medical Education and completed his residencies and chief residencies in neurology and neuropathology at NYU School of Medicine and New York-Presbyterian/Columbia University Medical Center, respectively.

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